The midfielder will wear the captain's armband at the AOK Stadion in the 4pm local time (3pm BST) kick-off - but regular skipper Jamaal Lascelles is fit enough to take a spot on the bench after returning to training this week.
Rob Elliot, who missed the weekend's game at Mainz due to illness, returns in goal but DeAndre Yedlin misses out.
Javier Manquillo, Ciaran Clark, Florian Lejeune and Paul Dummett are in defence, with Isaac Hayden partnering Shelvey in central midfield and Matt Ritchie and Christian Atsu on the flanks.
Ayoze Perez lines up behind Aleksandar Mitrovic, who is tasked with leading the line.
Rafa Benitez has also named 11 substitutes; Karl Darlow, Lascelles, Chancel Mbemba, Jesus Gamez, Jack Colback, Jacob Murphy, Mikel Merino, Siem de Jong, Rolando Aarons, Mohamed Diame and Dwight Gayle.
Newcastle United: Rob Elliot, Javier Manquillo, Ciaran Clark, Florian Lejeune, Paul Dummett, Matt Ritchie, Isaac Hayden, Jonjo Shelvey, Christian Atsu, Ayoze Perez, Aleksandar Mitrovic
Substitutes: Karl Darlow, Jamaal Lascelles, Chancel Mbemba, Jesus Gamez, Jack Colback, Jacob Murphy, Mikel Merino, Siem de Jong, Rolando Aarons, Mohamed Diame, Dwight Gayle.