The Swedish star, who had been sidelined with a toe injury, replaces Harvey Barnes in Eddie Howe's side for the Premier League clash with Brighton & Hove Albion.
Meanwhile, Kieran Trippier is injured so Tino Livramento comes into the Magpies backline.
And Lewis Miley is among the substitutes, 217 days since his last appearance following a back complaint towards the end of last season followed by a metatarsal injury sustained in the summer.
Dan Burn will line up against his former club - he spent four seasons on the South Coast before signing for United in January 2022 - with Bruno Guimarães wearing the captain's armband.
Newcastle United: Nick Pope, Fabian Schär, Joelinton, Sandro Tonali, Anthony Gordon, Alexander Isak, Lewis Hall, Tino Livramento, Jacob Murphy, Dan Burn, Bruno Guimarães (c)
Substitutes: Odysseas Vlachodimos, Harvey Barnes, Emil Krafth, Will Osula, Miguel Almirón, Lloyd Kelly, Joe Willock, Sean Longstaff, Lewis Miley