The Belgian goalkeeper has featured in the Magpies' last two games at this level, keeping a clean sheet in last month's Premier League Cup win over Southampton.
And he will again look to impress - and maintain his match fitness - in the 7pm kick-off at St. James' Park.
Frontman Luke Charman has scored three times in his last two matches, and will hope to add to that tally against the Hammers.
Daniel Barlaser, Yasin El-Mhanni, Curtis Good and Stuart Findlay, who have all played for the first team this season, will also be keen to catch the eye.
West Ham are one point and one place behind Newcastle in the race for a Premier League 2 Division Two play-off place.
Admission at St. James' Park is free to season ticket holders and members, otherwise £3 for adults and £1 concessions.