There's no getting around it, United do well to come away from Anfield with anything at all from a mightily impressive Liverpool side who look extremely strong from top to bottom.
But with the odds stacked against the Magpies, you may as well roll the dice and go for it.
Not many would have predicted Palace to win at Man City or Leicester to beat Chelsea and Newcastle are 22/1 to win the match at Anfield.
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Salomon Rondon has been in good form - and scored on his last visit to Merseyside when United drew at Everton. Back the big man to shock Anfield and score first at 14/1 with Coral.
Can Newcastle nick a 1-0 win? That’s a massive 50/1.
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Rafa Benítez is assured of a warm welcome at a place where he remains a very popular figure, but it's not a popularity contest and the boss would most likely give his right arm to come back from Merseyside with all three points in the bag.