The Lasses take on neighbours Durham Women at Kingston Park, with both teams having made extremely strong starts to the season.
And supporters will be able to watch the game live and exclusive on the Official Newcastle United App. Kick-off is at 14:00 (BST).
Becky Langley's newly-promoted Magpies have started their league campaign with seven points from a possible nine while Durham Women have won three of their four Women's Championship matches, so it promises to be a hard-fought and intriguing affair.
Former Lioness Demi Stokes scored her first goal for the club against the Toffees in midweek in a 1-1 draw, while fellow summer signing Amy Andrews will come up against her former club this weekend.
Sophie Haywood and Liv Watt were among those who came into the team on Wednesday night to give Langley a selection headache, and tickets for the game are on sale here, while season tickets - which cover all home league games - are still available from book.newcastleunited.com.
But fans who can't make the match can watch for free - anywhere in the world - via the Official Newcastle United App.
Download the Official Newcastle United App on the App Store or Google Play.