United were handed the clash with the Cottagers after easing past local rivals Sunderland in the third round earlier this month, where Alexander Isak's brace and a Dan Ballard own goal sealed a memorable 3-0 derby day victory.
Fellow Premier League side Fulham await Eddie Howe's charges' arrival in the capital this weekend, with a place in the last 32 of the famous competition up for grabs as United look to extend their cup run.
Howe's men have enjoyed an extended break from action following their agonising defeat to league champions Manchester City 11 days ago but have been working in the build-up to the trip to Craven Cottage this week.
Serena Taylor was at the Magpies' Benton training centre to bring nufc.co.uk this gallery from Newcastle's midweek preparations for the clash with Marco Silva's side.