Turnstiles will be open in the West Stand priced at £3 for adults and £1 for concessions.
Sunderland AFC have advised that supporters will not be segregated.
The fixture was originally set to take place at the Eppleton Colliery Welfare Ground in Hetton-le-Hole but was switched to the Stadium of Light due to recent adverse weather conditions.
The winners of Wednesday's quarter-final tie will face last year’s winners, FC Porto, in the last four.
Supporters can follow updates on Twitter at twitter.com/nufc, while Sunderland will be streaming the game live at facebook.com/sunderlandafc.