Eddie Howe has named the same starting XI as the previous two matches against Chelsea and Paris Saint-Germain, with a number of key players still sidelined.
Emil Krafth and Matt Ritchie return to the bench, having been ineligible for the PSG clash in midweek, while Lewis Hall was unable to face his parent club Chelsea last weekend but is also among the substitutes.
He scored his first goal for Newcastle against the Red Devils when the Magpies won 3-0 at Old Trafford in the Carabao Cup last month.
Nick Pope is in goal, with Kieran Trippier, Fabian Schär, captain Jamaal Lascelles and Tino Livramento making up the defence.
Lewis Miley joins Brazilian pair Bruno Guimarães and Joelinton in midfield, with Miguel Almirón, Anthony Gordon and Alexander Isak continuing in attack.
Martin Dúbravka, who spent part of last season on loan at Old Trafford, is one of two substitute goalkeepers, with Loris Karius - whose only Magpies appearance so far came against Manchester United in last season's Carabao Cup final - the other.
Other options for Howe from the bench are Hall, Ritchie, Krafth, Paul Dummett, Alex Murphy, Ben Parkinson and Amadou Diallo.
Newcastle United: Nick Pope, Kieran Trippier, Fabian Schär, Jamaal Lascelles (c), Tino Livramento, Bruno Guimarães, Lewis Miley, Joelinton, Miguel Almirón, Anthony Gordon, Alexander Isak
Substitutes: Martin Dúbravka, Loris Karius, Emil Krafth, Paul Dummett, Lewis Hall, Alex Murphy, Matt Ritchie, Amadou Diallo, Ben Parkinson