United exited the Carabao Cup at Chelsea in midweek and head coach Howe has opted to shuffle his pack a little, with the experienced defensive trio named in the starting 11 against the Hatters in place of Emil Krafth, Sven Botman and Tino Livramento.

Martin Dúbravka continues between the sticks, with Trippier, Jamaal Lascelles, Schär and Dan Burn forming a back four.

In front of them, Bruno Guimarães will operate as a number six, with teenager Lewis Miley and the more seasoned Sean Longstaff alongside him.

And up front there is the familiar attacking trio of Miguel Almirón, Anthony Gordon and Callum Wilson, who leads the line for United.

Alexander Isak is fit enough to be named on the bench, with Tuesday's starters at Stamford Bridge Krafth, Botman and Livramento also included.

Paul Dummett, Lewis Hall, Alex Murphy and Matt Ritchie are also among the substitutes, as is goalkeeper Loris Karius.

Newcastle United: Martin Dúbravka; Kieran Trippier, Jamaal Lascelles, Fabian Schär, Dan Burn; Lewis Miley, Bruno Guimarães, Sean Longstaff; Miguel Almirón, Callum Wilson, Anthony Gordon.

Substitutes: Loris Karius, Emil Krafth, Tino Livramento, Paul Dummett, Lewis Hall, Alex Murphy, Sven Botman, Matt Ritchie, Alexander Isak.