United take on Erik ten Hag's men just over a month on from their meeting in the Carabao Cup final at Wembley, with Howe's charges seeking revenge after that heartbreaking loss in the capital.
And he has opted to keep faith with the same side that started in their 2-1 win at Nottingham Forest last time out, though Joelinton and Anthony Gordon - who both missed that victory at the City Ground through suspension and injury respectively - are back in the squad.
Nick Pope continues in goal behind the settled backline of Kieran Trippier, Fabian Schär, Sven Botman and Dan Burn, with Bruno Guimarães anchoring the midfield and Sean Longstaff and Joe Willock lining up either side of the Brazilian.
Further forward, Jacob Murphy and matchday programme cover star Allan Saint-Maximin are deployed on the flanks, with the in-form Alexander Isak leading the line in attack.
Joelinton and Gordon are both back and on the bench, with Callum Wilson and Elliot Anderson also named.
There is plenty of defensive backup in the form of Javier Manquillo, Jamaal Lascelles, Matt Targett and Matt Ritchie, while Martin Dúbravka - who spent time on loan at Old Trafford earlier in the season - is the substitute goalkeeper.
Newcastle United: Nick Pope; Kieran Trippier, Fabian Schär, Sven Botman, Dan Burn; Sean Longstaff, Bruno Guimarães, Joe Willock; Jacob Murphy, Alexander Isak, Allan Saint-Maximin.
Substitutes: Martin Dúbravka, Javier Manquillo, Jamaal Lascelles, Matt Targett, Matt Ritchie, Joelinton, Elliot Anderson, Anthony Gordon, Callum Wilson.