The on-loan Inter Milan winger will line up against the champions, replacing Emil Krafth in the side as Steve Bruce’s men look to end the season on a high.
Austrian wideman Lazaro’s inclusion is the only change from the team which drew 0-0 at Brighton & Hove Albion on Monday night.
That means Martin Dúbravka maintains his ever-present record between the posts, with Javier Manquillo, Federico Fernández, Danny Rose and Matt Ritchie in front of him, shielded by a midfield partnership of Jonjo Shelvey and Nabil Bentaleb.
Lazaro, Allan Saint-Maximin and Miguel Almirón provide some attacking potency, with Dwight Gayle again set to lead the line for United.
Fit-again duo Isaac Hayden and Sean Longstaff are named as substitutes by Bruce, along with Joelinton and Andy Carroll, who could come on to face his former club.
Karl Darlow, DeAndre Yedlin and Yoshinori Muto are also on the bench, with youngsters Kelland Watts and Jack Young completing the list of replacements available for Newcastle’s final outing of this long season.
Newcastle United: Martin Dúbravka; Javier Manquillo, Federico Fernández, Danny Rose, Matt Ritchie; Jonjo Shelvey, Nabil Bentaleb; Valentino Lazaro, Miguel Almirón, Allan Saint-Maximin; Dwight Gayle.
Substitutes: Karl Darlow, DeAndre Yedlin, Kelland Watts, Isaac Hayden, Sean Longstaff, Jack Young, Yoshinori Muto, Joelinton, Andy Carroll.