The Magpies had been set to travel to Lancashire to face Erik ten Hag's men on Saturday, 20th April, but the Red Devils' involvement in the Emirates FA Cup semi-finals caused that fixture to be postponed.
It has now been announced that Eddie Howe's side will instead head to Old Trafford for the match on Wednesday, 15th May with kick-off set for 8pm BST.
The game will also be broadcast live on Sky Sports.
Ticket details will be confirmed on nufc.co.uk shortly.