But new signing Alexander Isak is not able to make his debut at Molineux as the Magpies are still awaiting international clearance for the Swedish star following his move from Real Sociedad on Thursday.Guimarães came on as a late substitute at Tranmere Rovers in midweek, but misses out at Wolves with a knock, while Wilson was withdrawn in the second half against Manchester City last weekend with a hamstring complaint.Nick Pope starts in goal, with Kieran Trippier captaining the side and Fabian Schär, Sven Botman and Dan Burn completing the United back line.In what will his 100th appearance for his boyhood club, Longstaff comes into midfield alongside Joelinton and Joe Willock, while Wood will lead the line with support from Allan Saint-Maximin and Miguel Almirón, who scored his first goal of the season against the champions last time out.Karl Darlow is the substitute goalkeeper while Matt Targett is on the bench after completing 45 minutes at Tranmere. Paul Dummett, Jamaal Lascelles, Javier Manquillo, Matt Ritchie, Jacob Murphy, Ryan Fraser and Elliot Anderson are the other subs.Newcastle United: Nick Pope, Kieran Trippier (c), Fabian Schär, Sven Botman, Dan Burn, Joelinton, Sean Longstaff, Joe Willock, Miguel Almirón, Allan Saint-Maximin, Chris WoodSubstitutes: Karl Darlow, Javier Manquillo, Matt Targett, Paul Dummett, Jamaal Lascelles, Matt Ritchie, Ryan Fraser, Jacob Murphy, Elliot Anderson