United lie in fourth place in Division Two - five points adrift of league leaders Southampton - and could join second-placed Wolves on 34 points with a victory at Whitley Park. They face an Aston Villa side situated in fifth, one point behind Ben Dawson's side.
United have already faced the Villans this term, with forward Elias Sørensen netting a hat-trick in an impressive 5-2 away win in October.
Newcastle have achieved successive clean sheets after recent away wins at Reading and Fulham while Villa are unbeaten in their last three league contests.
Admission is £3 for adults and £1 concessions. The match, taking place at Whitley Park, is free for season ticket holders and members.