And tickets for the event, dubbed 'The Big One', went on sale at 10am on Friday.
The day will see a curtain-raiser between Newcastle University and Northumbria University from 3pm, followed by the Falcons game from 5.30pm.
The Falcons are targeting what would be a record attendance of more than 20,000 and ticket prices start from £10 for adults and £5 for under-16s.
All advertised price categories will be on sale via the Newcastle Falcons box office, while tickets in categories one, two, five and premier can be bought from St. James' Park.
A £10 donation from every adult category two ticket and a £5 donation from every concession or under-16 category two ticket being made directly to the My Name’5 Doddie Foundation, set up by former rugby star Doddy Weir who has been diagnosed with motor neurone disease.
Newcastle Falcons' director of rugby, Dean Richards, said: "St. James' Park is an incredible stadium and this is a fantastic opportunity for us to take a game there.
"The passion for sport in our region and the commitment from the public in supporting major sporting events is second to none, and it will be a memorable day which people will want to be part of."
Club captain Will Welch added: "As a kid from this area I was brought up watching Newcastle United games at St. James' Park and experiencing the amazing atmosphere there.
"For us as Falcons players to now go play a game on that stage will be something truly special, and I'm sure our supporters and the wider public in our region will buy into it."
To book tickets for The Big One via the Newcastle United box office, click here, call 0844 372 1892 or visit St James' Park from 10am to 5pm, Monday to Friday or 9am to 4pm on Saturdays.