The game, which sees Becky Langley's FA Women's National League Northern Premier Division leaders travel to Marc Skinner's Women's Super League title contenders, has been selected for live coverage on The FA Player and the venue will be Leigh Sports Village, Manchester United Women's home ground.
Tickets for the fixture will be available to buy from 10:00 GMT on Friday, 22nd December. Seating is unreserved and tickets can be purchased from book.nufc.co.uk by selecting the 'NUW Team' tab.
All tickets will be in digital form and will be sent via email to the lead booker. A maximum of six tickets per transaction applies, with a £1 transaction booking fee.
Prices are:
Newcastle United Women season ticket holders
Adult: £9Under-16: £4.50Over-65: £4.50
(One ticket per holder at discounted rate)
General sale
Adult: £12Under-16: £6Over-65: £6
Newcastle United beat Mancunian Unity Women 9-2 in the first round and defeated Chorley Women 5-0 in the second before a victory by the same scoreline against Stoke City Women set up the clash with Manchester United Women, who include Lionesses Ella Toone and the newly-crowned BBC Sports Personalty of the Year Mary Earps among their squad.