One of those alterations is enforced, with Mikel Merino coming in for the injured Jonjo Shelvey in central midfield.
Jacob Murphy replaces Matt Ritchie on the right flank, while Christian Atsu has been preferred to Ayoze Pérez in the No. 10 role.
The remaining eight players have started in each of the Magpies’ last two fixtures – a 1-0 win over Manchester United at St. James’ Park, and last week’s 2-2 draw at AFC Bournemouth.
Martin Dúbravka continues in goal, with Paul Dummett, Florian Lejeune, Jamaal Lascelles and DeAndre Yedlin again making up the back four from left to right.
Merino will partner Mohamed Diamé in the engine room, with Kenedy retaining his place on the left wing and Dwight Gayle doing the same as a lone frontman.
Newcastle United: Martin Dúbravka, DeAndre Yedlin, Jamaal Lascelles, Florian Lejeune, Paul Dummett, Mohamed Diamé, Mikel Merino, Christian Atsu, Jacob Murphy, Kenedy, Dwight Gayle.
Substitutes: Karl Darlow, Ciaran Clark, Javier Manquillo, Isaac Hayden, Matt Ritchie, Ayoze Pérez, Joselu.