Ciaran Clark, Matt Ritchie and Ayoze Pérez all come into the starting line-up at the expense of Javier Manquillo, Fabian Schär and Jacob Murphy, with the Magpies reverting to a back four for the Premier League clash at St. James’ Park.
Martin Dúbravka continues in goal, with DeAndre Yedlin, Jamaal Lascelles, Federico Fernández and Clark at the back.
Ritchie, who was suspended for the midweek draw at Everton, comes back into the side on the right side of midfield, with Mo Diamé and Ki Sung-yueng in the middle and Christian Atsu on the left.
And Pérez is back in attack, where he will provide support for Salomón Rondón.
Defender Paul Dummett returns from injury to take his place on the bench, with Freddie Woodman, Manquillo and Sean Longstaff.
Kenedy, Yoshinori Mutō and Joselu complete the list of replacements available to Benítez.
Newcastle United: Martin Dúbravka; DeAndre Yedlin, Jamaal Lascelles, Federico Fernández, Ciaran Clark; Matt Ritchie, Mo Diamé, Ki Sung-yueng, Christian Atsu; Ayoze Pérez; Salomón Rondón.
Substitutes: Freddie Woodman, Javier Manquillo, Paul Dummett, Sean Longstaff, Kenedy, Yoshinori Mutō, Joselu.