As they did against Chelsea on Sunday, United line up with a five-man backline, with Paul Dummett on the left, DeAndre Yedlin on the right, and Lascelles joining Ciaran Clark and Federico Fernández in the centre.
Mohamed Diamé and Ki Sung-yueng have been picked to play in the middle of the park, with Kenedy – back in Premier League action after missing Sunday’s defeat to his parent club – and Ayoze Pérez deployed out wide.
Up front, Salomón Rondon – who scored his first goal for the club in Wednesday’s Carabao Cup defeat to Nottingham Forest – replaces Joselu, who drops to the bench.
Young duo Jamie Sterry and Sean Longstaff also feature among United’s list of substitutes, joining wide-men Christian Atsu and Jacob Murphy, as well as Karl Darlow and Yoshinori Muto.
Newcastle United: Martin Dúbravka, DeAndre Yedlin, Federico Fernández, Jamaal Lascelles, Ciaran Clark, Paul Dummett, Mohamed Diamé, Ki Sung-yueng, Kenedy, Ayoze Pérez, Salomón Rondón.
Substitutes: Karl Darlow, Jamie Sterry, Sean Longstaff, Christian Atsu, Jacob Murphy, Yoshinori Muto, Joselu.