The Swiss international - who joined the club from Deportivo La Coruña on Thursday - is among the substitutes at Estádio do Dragão.
Martin Dúbravka starts in goal and will make his first appearance of pre-season, as will Paul Dummett at left-back. DeAndre Yedlin is at right-back, with Ciaran Clark partnering skipper Jamaal Lascelles in central defence.
Matt Ritchie and Jacob Murphy are on the wings and Mohamed Diamé and Jonjo Shelvey are in the heart of midfield. Ayoze Pérez - who turns 25 on Sunday - starts just behind Joselu.
Joining Schär on the bench are Karl Darlow, Rob Elliot, Javier Manquillo, Jamie Sterry, Josef Yarney, Isaac Hayden, Ki Sung-yueng, Sean Longstaff, former Porto man Christian Atsu, Víctor Fernández, Callum Roberts, Adam Armstrong and Dwight Gayle.
Newcastle United: Martin Dúbravka; DeAndre Yedlin, Ciaran Clark, Jamaal Lascelles (c), Paul Dummett; Matt Ritchie, Mohamed Diamé, Jonjo Shelvey, Jacob Murphy; Ayoze Pérez; Joselu.
Subs: Karl Darlow, Rob Elliot, Javier Manquillo, Fabian Schär, Jamie Sterry, Josef Yarney, Isaac Hayden, Ki Sung-yueng, Sean Longstaff, Christian Atsu, Víctor Fernández, Callum Roberts, Adam Armstrong, Dwight Gayle.