The Magpies head to the London Stadium looking for a third league win on the bounce, and manager Benítez has opted to keep faith with the team that beat Burnley 2-0 at St. James’ Park on Tuesday night.
That means Martin Dúbravka continues in goal, with Javier Manquillo and Matt Ritchie on the flanks in front of him and Fabian Schär, Jamaal Lascelles and Florian Lejeune in defence.
Isaac Hayden and Sean Longstaff start in the middle once more, while frontman Salomón Rondón will spearhead Newcastle’s attack with support from Ayoze Pérez and Miguel Almirón.
Karl Darlow is on the bench, along with DeAndre Yedlin, Paul Dummett and Ki Sung-yueng.
Mo Diamé is also among the substitutes, while Christian Atsu and Yoshinori Muto offer more attacking alternatives.
Newcastle United: Martin Dúbravka; Javier Manquillo, Fabian Schär, Jamaal Lascelles, Florian Lejeune, Matt Ritchie; Isaac Hayden, Sean Longstaff; Ayoze Pérez, Salomón Rondón, Miguel Almirón.
Substitutes: Karl Darlow, DeAndre Yedlin, Paul Dummett, Mo Diamé, Ki Sung-yueng, Christian Atsu, Yoshinori Muto.