Full back Javier Manquillo comes into the starting 11 at the expense of Ciaran Clark, who captained United and scored what proved to be the winner in Monday night’s 2-1 victory at Burnley.
Martin Dúbravka continues in goal, with DeAndre Yedlin, Federico Fernández, Fabian Schär and Manquillo at the back.
The midfield is unchanged, with Matt Ritchie, Mo Diamé, Ki Sung-yueng and Kenedy looking to provide the ammunition for Ayoze Pérez and, further forward, Salomón Rondón in attack.
Skipper Jamaal Lascelles returns to the bench after injury, with Freddie Woodman, Ciaran Clark, and Jonjo Shelvey also among the substitutes.
Youngster Sean Longstaff is also among the replacements, along with Christian Atsu and Joselu.
Newcastle United: Martin Dúbravka; DeAndre Yedlin, Federico Fernández, Fabian Schär, Javier Manquillo; Matt Ritchie Mo Diamé, Ki Sung-yueng, Kenedy; Ayoze Pérez; Salomón Rondón.
Substitutes: Freddie Woodman, Jamaal Lascelles, Ciaran Clark, Jonjo Shelvey, Sean Longstaff, Christian Atsu, Joselu.