Miley - the older brother of Lewis - featured at senior level last pre-season, making his bow against Gateshead, but starts for the club for the first time at the MKM Stadium.
The 20-year-old, born in Stanley, was shortlisted for the Premier League 2 Player of the Month award for May and primarily plays in central midfield.
Nick Pope is in goal, with Jamal Lewis handed an opportunity to impress in black and white after spending last term on loan with Watford.
Blyth-born Dan Burn captains the team, with Alexander Isak leading the line.
Joining experienced goalkeepers Odysseas Vlachodimos and John Ruddy on the bench are a number of the club's promising Academy players, including Australia international Garang Kuol and Durham-born forward Ben Parkinson, who made his Premier League debut at AFC Bournemouth last season.
Newcastle United: Nick Pope, Joelinton, Harvey Barnes, Jamal Lewis, Alexander Isak, Emil Krafth, Lewis Hall, Tino Livramento, Jacob Murphy, Dan Burn (c), Jamie Miley
Substitutes: Odysseas Vlachodimos, John Ruddy, Garang Kuol, Jay Turner-Cooke, Cathal Heffernan, Ben Parkinson, Ellis Stanton, Ciaran Thompson, Alfie Harrison, Dylan Charlton, Johnny Emerson, Anthony Munda, Trevan Sanusi