It’s Manquillo’s first start since last month’s Emirates FA Cup defeat to Watford at St. James’ Park, though the Spaniard did feature as a substitute against both Manchester City and Wolverhampton Wanderers.

He takes over Yedlin’s place on the right of a five-man backline, which includes Matt Ritchie on the opposite flank and Jamaal Lascelles, Florian Lejeune and Fabian Schär in the centre.

Isaac Hayden and Sean Longstaff continue together in central midfield, with Miguel Almirón – fresh from an impressive full debut – and Ayoze Pérez supporting leading goalscorer Salomón Rondón.

Freddie Woodman and Kenedy drop out of United’s list of substitutes, with the pair replaced by Karl Darlow and Mohamed Diamé respectively.

Yedlin – who had previously started each of the Magpies’ Premier League games since 22nd December – is among those to join them on the bench.

Newcastle United: Martin Dúbravka, Javier Manquillo, Fabian Schär, Jamaal Lascelles, Florian Lejeune, Matt Ritchie, Isaac Hayden, Sean Longstaff, Miguel Almirón, Ayoze Pérez, Salomón Rondón.

Substitutes: Karl Darlow, DeAndre Yedlin, Paul Dummett, Ki Sung-yueng, Mohamed Diamé, Christian Atsu, Joselu.