Manquillo – 24 today – replaces DeAndre Yedlin at right back, with the American dropping to the bench. Murphy, meanwhile, starts for Newcastle for the first time since 3rd March, preferred to Matt Ritchie on the right flank.
Martin Dúbravka continues in goal, with Paul Dummett, captain Jamaal Lascelles and Florian Lejeune all keeping their place in the Magpies’ backline.
Mohamed Diamé and Jonjo Shelvey again pair up in central midfield, with Kenedy – who spent a brief period on loan at Vicarage Road last season – wide on the left.
Ayoze Pérez starts in the No. 10 role once more, with Dwight Gayle up front on his own. With Islam Slimani suspended, Joselu is the only other out-and-out striker Rafa Benítez will be able to call upon this afternoon.
Newcastle United: Martin Dúbravka, Javier Manquillo, Jamaal Lascelles, Florian Lejeune, Paul Dummett, Jacob Murphy, Mohamed Diamé, Jonjo Shelvey, Kenedy, Ayoze Pérez, Dwight Gayle.
Substitutes: Karl Darlow, DeAndre Yedlin, Massadio Haïdara, Isaac Hayden, Mikel Merino, Matt Ritchie, Joselu.