The Brazilian, who joined on loan from Chelsea last week, will start on the right side of midfield as Magpies boss Rafa Benítez rings the changes after Sunday’s FA Cup defeat at Chelsea.
Karl Darlow continues in goal, with DeAndre Yedlin, Jamaal Lascelles, Ciaran Clark and Paul Dummett making up the back four.
Christian Atsu will start wide on the right, with Mohamed Diamé and Mikel Merino starting in the middle, and 21-year-old Kenedy on the left.
And Ayoze Pérez will provide support for lone frontman Joselu in attack.
Freddie Woodman is named on the bench with Javier Manquillo and Isaac Hayden, while Jonjo Shelvey and Jacob Murphy are also among the substitutes.
Matt Ritchie and Dwight Gayle complete the list of players available for Benítez to call upon from the sidelines against the Clarets.
Newcastle United (4-4-1-1): Karl Darlow; DeAndre Yedlin, Jamaal Lascelles, Ciaran Clark, Paul Dummett; Christian Atsu, Mohamed Diamé, Mikel Merino, Kenedy; Ayoze Pérez; Joselu.
Substitutes: Freddie Woodman, Javier Manquillo, Isaac Hayden, Jonjo Shelvey, Matt Ritchie, Jacob Murphy, Dwight Gayle.