The Brazilian frontman replaces Callum Wilson up top, with United’s leading goalscorer failing a late fitness test after hobbling out of their last game, at Southampton a fortnight ago, with a hamstring injury.
Also coming into Newcastle’s line-up are Javier Manquillo, Ciaran Clark and Isaac Hayden. The latter comes in for Jeff Hendrick in midfield, the Irish international dropping to the bench.
Manquillo starts at right wing back, with Jacob Murphy pushing further forward to compensate for the absence of Miguel Almirón, who only returned from international duty with Paraguay late on Thursday night.
Clark, meanwhile, starts for the first time since September’s thumping Carabao Cup victory at Morecambe.
Almirón does make the substitutes’ bench, where he is joined by the likes of Fabian Schär, Andy Carroll and the fit-again Jonjo Shelvey.
Newcastle United: Karl Darlow, Javier Manquillo, Jamaal Lascelles, Federico Fernández, Ciaran Clark, Jamal Lewis, Jacob Murphy, Sean Longstaff, Isaac Hayden, Allan Saint-Maximin, Joelinton.
Substitutes: Mark Gillespie, Emil Krafth, Fabian Schär, Jeff Hendrick, Jonjo Shelvey, Miguel Almirón, Andy Carroll.