The Magpies quickly return to action for their final pre-season fixture of the 2022/23 campaign less than 24 hours after a 1-0 win over Serie A outfit Atalanta on home soil, courtesy of Chris Wood's penalty.
Botman, who joined the Magpies earlier this month from Ligue 1 side LOSC Lille, will partner captain Jamaal Lascelles at the heart of United's defence, with Emil Krafth and Paul Dummett occupying the respective flanks. Martin Dúbravka will start in-between the sticks.
Joelinton, who received a red card against Benfica at the Estádio da Luz on Tuesday night, returns from a one-match suspension and is situated alongside fellow Brazilian Bruno Guimarães in the middle of the park as well as Joe Willock.
Matt Ritchie and Allan Saint-Maximin both start on the wings and will aim to provide attacking support for striker Callum Wilson.
The bench remains the same as Friday night's win over Atalanta, with Dylan Stephenson - who made his first-team debut for his boyhood club as a stoppage-time substitute last night - available to deploy along with the likes of Matty Longstaff, Matt Bondswell and Santiago Muñoz.
Alex Murphy, who joined the Magpies' youth set-up from hometown club Galway United, along with teenage trio Lucas De Bolle, Jay Turner-Cooke and Lewis Miley could be in line to make their first-team bows for Newcastle.
Newcastle United: Martin Dúbravka, Emil Krafth, Jamaal Lascelles (c), Sven Botman, Paul Dummett, Joelinton, Bruno Guimarães, Joe Willock, Matt Ritchie, Allan Saint-Maximin, Callum Wilson.
Substitutes: Mark Gillespie, Alex Murphy, Matt Bondswell, Matty Longstaff, Lewis Miley, Lucas De Bolle, Jay Turner-Cooke, Santiago Muñoz, Dylan Stephenson.