With the Magpies chasing a first Premier League win in more than a month, Darlow – whose only prior appearance this term came in August’s Carabao Cup defeat to Nottingham Forest at St. James’ Park – has been preferred to Rob Elliot in goal.

There are four changes elsewhere, including a switch at left back, where Chancel Mbemba comes in for Javier Manquillo.

The central midfield pair who started Saturday’s 3-0 defeat to Watford both drop to the bench, with Isaac Hayden and Mikel Merino replacing Mohamed Diamé and Jonjo Shelvey.

Ayoze Pérez also returns as Benítez opts for a 4-2-3-1 formation once more, the Spaniard set to play in the No. 10 role behind his fellow countryman, Joselu.

Dwight Gayle and Aleksandar Mitrović are both listed among United’s substitutes, as well as Rolando Aarons, who has only made two first-team appearances so far this season.

Newcastle United: Karl Darlow, DeAndre Yedlin, Florian Lejeune, Ciaran Clark, Chancel Mbemba, Isaac Hayden, Mikel Merino, Matt Ritchie, Ayoze Pérez, Jacob Murphy, Joselu.

Substitutes: Rob Elliot, Javier Manquillo, Mohamed Diamé, Jonjo Shelvey, Rolando Aarons, Dwight Gayle, Aleksandar Mitrović.