The Paraguayan international impressed after coming off the bench in the 2-0 opening-day win at West Ham earlier this month and also starred in the 7-0 Carabao Cup win over Morecambe in midweek.

And his reward is a start at the Tottenham Hotspur Stadium, where he helped Steve Bruce’s side earn a 1-0 win last term on what was their first visit to the new ground.

Bruce has also opted to start forward Joelinton, who bagged a brace at the Mazuma Stadium on Wednesday night, with winger Allan Saint-Maximin missing out through injury.

Karl Darlow starts in goal, with Jamaal Lascelles and Federico Fernández forming a central defensive partnership and Javier Manquillo and Matt Ritchie as full backs.

Jonjo Shelvey and Isaac Hayden will line up in midfield, along with summer signing Jeff Hendrick – who netted on his Magpies debut against the Hammers on their last trip to the capital.

And it will be a three-pronged attack for United, with Almirón, Callum Wilson and Joelinton forming a forward line.

Andy Carroll, Jamal Lewis and Jacob Murphy are all on the bench, and Mark Gillespie, DeAndre Yedlin, Emil Krafth and Sean Longstaff are also among the substitutes.

Newcastle United: Karl Darlow; Javier Manquillo, Jamaal Lascelles, Federico Fernández, Matt Ritchie; Jonjo Shelvey, Isaac Hayden, Jeff Hendrick; Miguel Almirón, Callum Wilson, Joelinton.

Substitutes: Mark Gillespie, DeAndre Yedlin, Emil Krafth, Jamal Lewis, Sean Longstaff, Jacob Murphy, Andy Carroll.