With Newcastle fighting for automatic promotion and Preston eyeing a play-off place, Sky Sports will show the game from St. James' Park.
As a result, the fixture will be played on Monday, 24th April (kick-off 7.45pm) rather than its previous date of Saturday, 22nd April at 3pm.
United were 2-1 winners at Deepdale in October, with Aleksandar Mitrovic scoring both goals, while the Magpies won 6-0 in the EFL Cup on Tyneside in the same month.