Peter Beardsley's under-23s will play home and away against Burnley, Swansea City and Colchester United.
And the Magpies have confirmed that all three of their Group D home fixtures will be played at Whitley Park, the Northumberland FA's headquarters in Benton.
United will face Burnley on Friday, 29th September. They then entertain Swansea on Monday, 12th February 2018 and Colchester on Monday, 26th February 2018.
Kick-off for all three matches will be 1pm UK time.
Newcastle travel to Swansea (venue TBC) on Friday, 3rd November for a 1pm kick-off and Colchester's Weston Homes Community Stadium on Monday, 4th December (kick-off 7pm). Stockport County's Edgeley Park will host the Burnley game on Thursday, 18th January (kick-off 2pm).