Becky Langley's side will take on the Wanderers Women, who are top of the FA Women's National League Northern Premier Division - one league above the Magpies - on Sunday, 11th December at Kingston Park.
Tickets for the game are on sale in advance here, priced at £3 for adults and £1 concessions. Parking can be booked here.
United beat Barnsley Women in front of 28,565 supporters, a new record for the competition outside of a final, thanks to stunning goals from Georgia Gibson and Sharna Wilkinson.
And manager Langley told nufc.co.uk: "Wolves will be a tough test - a team top of tier three. We have had some close-fought battles in the past with Wolves and I don't think this time will be anything less.
"A couple of the girls I've previously coached at English Universities and who I played with at Loughborough Uni will be playing, some good players, so we will be trying to make sure they have a quiet afternoon."
Kick-off at Kingston Park on Sunday, 11th December is at 1pm (GMT). Newcastle United Women season tickets are valid for this game.