Peter Beardsley and Ben Dawson's side will again compete in Division Two of the competition - after agonisingly missing out of promotion through the play-offs last season - alongside fellow under-23 teams from the likes of Southampton, Aston Villa and Middlesbrough.
The Magpies, who will also compete in the Checkatrade Trophy and the Premier League Cup this season, face three away trips to kick-off their league season in August, before welcoming Norwich City to Tyneside for their first home game on Monday, 11th September.
That clash with the Canaries is one of three matches scheduled to be played at St. James' Park, with the visits of Wolverhampton Wanderers on Monday, 25th September and Aston Villa on Monday, 5th March also set to be played at St. James'.
All of United's other home fixtures will be played at Whitley Park, adjacent to the club's Benton training base.
Among the stadiums the young Magpies will visit this term are The Hawthorns, St. Mary's and Carrow Road.
All fixtures are subject to change. A full fixture list can be found below.
Newcastle United Under-23s Premier League 2 fixtures 2017/18
August
Saturday 12th Stoke City (a) 2pm Friday 18th West Bromwich Albion (a) 7pm Friday 25th Middesbrough (a) 7pm
September
Monday 11th Norwich City (h) 7pm Monday 18th Brighton & Hove Albion (a) 7pm Monday 25th Wolverhampton Wanderers (h) 7pm
October
Monday 16th Southampton (a) 7pm Monday 23rd Blackburn Rovers (h) 7pm Monday 30th Aston Villa (a) 7pm
November
Monday 20th Reading (h) 7pm Friday 24th Fulham (a) 2pm
December
Monday 11th West Bromwich Albion (h) 7pm Monday 18th Stoke City (h) 7pm
January
Monday 8th Middlesbrough (h) 7pm Sunday 14th Norwich City (a) 2pm Monday 29th Brighton & Hove Albion (h) 7pm
February
Monday 5th Wolverhampton Wanderers (a) 7pm Monday 19th Southampton (h) 7pm
March
Monday 5th Aston Villa (h) 7pm Monday 12th Blackburn Rovers (a) 7pm
April
Monday 16th Reading (a) 7pm Monday 23rd Fulham (h) 7pm
