Newcastle United beat Luton Town 3-1 at St. James' Park in the third round, with Ayoze Pérez scoring twice and Jonjo Shelvey also on target.
And the fourth round draw will take place ahead of Monday's tie between Brighton & Hove Albion and Crystal Palace.
Jake Humphrey will host the draw, which will be made at the Amex Stadium at about 7.10pm and screened on BBC Two and BT Sport. Supporters can also check nufc.co.uk and the club's social media channels to discover Newcastle's opponents.
Rafa Benítez's side will be ball number 27.
Fourth round ties will take place across the weekend of 26th, 27th, 28th and 29th January.