Newcastle enter the competition at this stage, with the draw taking place live on Sky Sports ahead of Sunderland's first round tie against Sheffield Wednesday.
Former Magpie Chris Waddle will join Mick McCarthy to conduct the draw alongside David Prutton from 7pm (BST). The second round draw sees the inclusion of the 13 Premier League clubs who are not competing in European competitions, alongside Sky Bet Championship sides Stoke City and Swansea City.
The draw is unseeded but will be regionalised into North and South sections.
The remaining seven Premier League clubs will enter the competition in round three.
Newcastle will be ball number 17 in the North section.