Steve Cooper's side, who beat Huddersfield Town in the Sky Bet Championship play-off final at Wembley last month, are due to begin their first season back in the top flight on Tyneside on Saturday, 6th August with a 3pm (BST) kick-off.
The Magpies then face a long trip to Brighton & Hove Albion the following weekend before champions Manchester City come to St. James' Park on Saturday, 20th August. Eddie Howe's side will join the Carabao Cup at the second round stage, with ties due to be played on or around Wednesday, 24th August.
There's a midweek trip to Merseyside on Wednesday, 31st August to take on Liverpool while AFC Bournemouth come to Newcastle on Saturday, 17th September - a clash which is sure to be an emotional one for head coach Howe and the likes of Callum Wilson and Ryan Fraser.
United are at Manchester United on Saturday, 15th October (although this is subject to the Red Devils' European commitments) before, following a home game with Chelsea on Saturday, 12th November, the season pauses for the World Cup in Qatar.
The Magpies are set to return to action at Leicester on Boxing Day, before hosting Leeds United on New Year's Eve and kicking off 2023 at Arsenal on Monday, 2nd January.
Newcastle will end the campaign at Chelsea on Sunday, 28th May.
You can sync Newcastle United's 2022/23 fixtures to your calendar here. All dates are subject to change due to live television selections. August and September broadcast selections are due to be announced next month, while October's games are also expected to be confirmed at the end of July.
November's games are due to be announced by 13th September, with any changes to December and January's fixtures expected to be announced by 11th October.