Atsu will take on Sissoko - who is representing current club Tottenham Hotspur - in a video game clash streamed LIVE on Sky Sports’ YouTube and Twitch accounts and online Premier League channels at 3:45pm (BST) on Wednesday 22nd April.
What is the ePremier League Invitational?
The ePremier League Invitational tournament will see familiar faces involved with all 20 Premier League clubs playing FIFA 20 in a cup format.
It kicks off with a knock-out round from Tuesday 21st April, before a grand final event - including the semi-finals and finals - live on Sky Sports Main Event and Sky Sports Premier League at 3pm on Sunday 25th April.
Who is taking part?
All but two Premier League clubs are being represented by first team players, with Raheem Sterling (Manchester City), Trent Alexander-Arnold (Liverpool), Wilfried Zaha (Crystal Palace), André Gomes (Everton) and Diogo Jota (Wolves) all taking part.
Manchester United are being represented by singer Tom Grennan, while You Me At Six frontman Josh Franceschi will feature for Arsenal.
The FULL ePremier League Invitational Draw
The draw for the online esports tournament, which features familiar faces from all 20 Premier League clubs, was made live on Sky Sports on Monday 20th April by Jamie Redknapp and his son, Beau.
Along with 11 other players, Atsu has received a bye in Round 1.
Here is the full ePremier League Invitational draw:
Round 121 April (from 12pm BST)12pm 1A John McGinn (AVL) v Neal Maupay (BHA)1:15pm 1B Josh Franceschi (ARS) v Nathaniel Chalobah (WAT)2:30pm 1C Dwight McNeil (BUR) v Ryan Fredericks (WHU)3:45pm 1D Philip Billing (BOU) v Angus Gunn (SOU)
Last 1622 April (from 12pm BST)12pm 2A Raheem Sterling (MCI) v Wilfried Zaha (CRY)1:15pm 2B Tom Grennan (MUN) v Trent Alexander-Arnold (LIV)2:30pm 2C Reece James (CHE) v Andre Gomes (EVE)3:45pm 2D Moussa Sissoko (TOT) v Christian Atsu (NEW)
23 April (from 12pm BST)12pm 2E Diogo Jota (WOL) v James Justin (LEI)1pm 2F Todd Cantwell (NOR) v Lys Mousset (SHU) 2pm 2G Winner 1A v Winner 1D 3pm 2H Winner 1B v Winner 1C
Quarter-finals24 April (from 12pm BST)QF1 Winner 2B v Winner 2DQF2 Winner 2C v Winner 2AQF3 Winner 2E v Winner 2FQF4 Winner 2G v Winner 2H
Semi-finals/Final25 April (from 3pm BST)SF1 Winner QF1 v Winner QF2SF2 Winner QF3 v Winner QF4FINAL Winner SF1 v Winner SF2
Should Atsu beat Sissoko, he will face the winner of the clash between singer Tom Grennan (representing Manchester United) and Trent Alexander-Arnold (Liverpool) on Friday 24th April.
The ePL Invitational tournament is operated by esports tournament organisers Gfinity.
For more information visit premierleague.com/epl-invitational.