The league leaders go in off the back of disappointment in Europe following Real Madrid's remarkable late turnaround at the Bernabeu in midweek, while the Magpies are also looking to bounce back from the narrow defeat to Liverpool.
Only Jurgen Klopp's side and fellow title contenders Man City, however, can better Newcastle's league form over the last 15 matches and the recent run of four wins in the last five has catapulted Eddie Howe's men into the top half of the table with just three fixtures left on the schedule.
The chances of Newcastle putting a huge dent in City's title aspirations are rated at 14/1 and at the very least fans can expect goals in a fixture that has delivered an average of four per game in the last six head-to-heads.
Punters unnerved by that underdog status can now snap up one of several price boosts now live on the BoyleSports app, with an away win by 1-0, 2-0 or 2-1 enhanced from 14/1 to 16/1, scorelines which cover each of Newcastle's last three victories over Manchester City.
Three of Newcastle's last four away wins have also come by 1-0, 2-0 and 2-1 scorelines and anyone confident enough of the team getting back on the coach with a 1-0 win under their belts can get odds 33/1, while Chris Wood is rated the most likely to find the net for the visitors.
He is a 4/1 shot to score at anytime during the match, but Brazilian pair Joelinton (5/1) and Bruno Guimaraes (15/2) are also popular in the anytime goalscorer betting should Newcastle trouble the league leaders' defence on Sunday.
Newcastle to win 1-0, 2-0 or 2-1 was 14/1... now 16/1.
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