Pérez's stoppage-time heroics (2015/16)
United secured an important 2-1 victory as the Magpies came from behind to stun Tottenham in the dying stages at White Hart Lane.
Following Eric Dier's first-half header, the introduction of forwards Aleksandar Mitrović and Ayoze Pérez proved crucial as both substitutes got their name on the scoresheet.
After replacing Papiss Cissé, Mitrović took just two minutes to find United's equaliser after coming on, scrambling the ball home from close-range.
The Serbian striker then turned provider for Pérez, flicking a cross into the path of the Spaniard who fired home in the 93rd minute to seal a dramatic third consecutive away league win against Spurs.
Joelinton's winner (2019/20)
Joelinton netted his first competitive goal for Newcastle as the Magpies secured a 1-0 victory at the Tottenham Hotspur Stadium in August 2019.
The Brazilian completed a fine passing move from the visitors, controlling Christian Atsu's swinging cross before slotting the ball home in front of the jubilant away supporters.
The hosts controlled the large majority of possession but United defended valiantly, holding on for an impressive win in the basking North London sunshine.
Krul breaks Premier League record (2013/14)
Loic Remy's 13th minute strike proved to be the difference in a game that would be mainly remembered for the goalkeeping heroics of United goalkeeper Tim Krul.
After Remy rounded Brad Friedel to net his seventh goal in seven appearances, the Dutch shot-stopper made 14 saves - the most by any goalkeeper in Premier League history at the time - to produce one of the finest individual performances of the 2013/4 season and record a tremendous clean sheet.
The win was the Magpies' second of four consecutive Premier League victories as Alan Pardew's side went unbeaten during November before finishing their campaign in tenth place.
Martins' missile (2006/07)
United came from behind twice as the Magpies claimed a 3-2 victory, with Obafemi Martins' thunderbolt proving the pick of the five goals at White Hart Lane.
Spurs took a 14th minute lead through Jermain Defoe before defender Paul Huntington replied two minutes later and, despite Dimitar Berbatov regaining Tottenham's lead, it took 94 seconds for the Magpies to turn the game on its head.
The Nigerian forward levelled the scoreline after unleashing an astonishing strike, clocked at 84mph, which flew ferociously into the top corner.
Nicky Butt, who had been suffering from flu that week, delivering a sickening blow to the hosts, getting on the end of Martin's delightful through ball before finding the net from a tight angle.
One nil down, four one up! (2007/08)
Another five-goal thriller saw United turn on the style with a dominant second-half display to record a 4-1 win in the capital.
After Nicky Butt cancelled out Darren Bent's opener on the stroke of half-time, Geremi's free kick sent the Magpies into the lead shortly after the restart before Michael Owen doubled the visitors' lead with a composed finish.
Obafemi Martins' impressive solo finish, his fourth goal in a row against Spurs, confirmed an excellent league win on the road as the Magpies sealed their fifth consecutive win in a row against the Lilywhites.