The Magpies head to the capital aiming to inflict the Bees' first defeat at the Gtech Community Stadium since the Magpies' 4-2 away win on the final day of the 2023/24 campaign.
After a six-goal thriller against Liverpool, leading twice against the Premier League leaders before salvaging a point in the final stages following Fabian Schär's leveller, Howe is aiming for his side to replicate similar levels shown in their previous league fixture at St. James' Park.
Here are some of the boss' main talking points from Friday morning's pre-match media briefing at the Newcastle United Media Centre...
On a swift return to action:
"It's one of the challenges we face going into this game. The players would have felt the high of the Liverpool game and there's always a comedown like that after any game.
"Our challenge this weekend is to find a way to hit the same levels of intensity and mental quality that we showed on Wednesday. There were some tired bodies in the team after the game, with Sandro (Tonali) getting cramp with ten or 15 minutes to go.
"Anthony (Gordon) was fatigued at the end of his performance which was very good and Alex (Isak) worked extremely hard and was tired. Our job is refuel, regroup and go again for what is another great opportunity."
On creating the right mindset:
"Attitude is everything to any team and against Liverpool you saw the correct attitude and mental preparation from the players. There was really good energy and bite in midfield, with desire to win the ball and winning our duels.
"Athletically, we looked good against a top team, especially in the first-half."
On Schär, who netted an impressive equaliser in Wednesday's 3-3 draw against Liverpool:
"Fabian has got those midfield qualities at centre-back. He has got that creative eye that has been so important in our build-up phases.
"Everyone attacks, has a responsibility to attack and Fabian really carries that burden and how he distributes the ball. He used the ball well against Liverpool, both long and short.
"His goal is rounding everything up and it's a great example of him. How he scored from that angle is beyond me but he has that technical ability to adapt and he’s scored some wonderful goals for us."
On the trip to Brentford, who are currently unbeaten on home soil this season as well as netting 26 times in nine competitive matches:
“Whenever you go away from home, the intention that you set in the game is key and the early exchanges give you a lot of clues to how the game is going to go.
"We need to start well and we're well aware that Brentford score a lot of early goals. We need to find a way to win, this is a massive one for us.
"I am very positive about what we can deliver. It is a tough assignment at Brentford as they have been in good form.”
On Wednesday’s midfield three, which saw Bruno Guimarães, Joelinton and Tonali all start against the Reds:
“I thought the midfield three worked very well and I thought they had to in that game. I thought we were very good in that department, especially in the first 45 minutes, and their positioning on the pitch was really good.
"There was a lot of fluid movements and rotations but, still, the structure was what I wanted it to be. Bruno ends up creating one goal from the number six position and one slightly higher up, which is great to see. We want to be a progressive team.”
On Sven Botman's progress from an anterior cruciate ligament injury sustained in March:
“He is doing well. The initial moments in training were passive and making sure he didn't do too many drills but now he is fully training, playing a couple of 11v11s.
"He is still a a few weeks off from playing competitively but he looks and feels good. It's all about rhythm for Sven now and getting those game dynamics and the pitch geography back, things he would normally do on auto-pilot.
"He needs to rediscover how to do it but it's been a big boost to have him training. He is a big guy, a big presence and we have missed him.”
