Newcastle's youngsters netted three times in the first-half at the Magpies' Little Benton Academy courtesy of Shaun Mavididi's opener and strikes from Jamie Miley and Michael Ndiweni.
Ndiweni added a fourth shortly after the hour mark before the Throckley-born forward netted his hat-trick in the closing stages following Kyle Crossley's composed finish.
Newcastle's Academy were aiming to build on a 2-1 win against Austria Vienna following a 2-1 win in Salou earlier this month.
Miley, older brother of Lewis who scored his first goal for United's under-21 side in a 2-1 defeat against Sheffield United's second-string, saw a teasing corner parried onto the top of the crossbar by the visiting goalkeeper.
In the 17th minute, the hosts took the lead as Mavididi, who joined the Magpies' youth set-up from Arsenal in the summer of 2021, opened the scoring in emphatic fashion.
After right-back Josh Stewart advanced towards the byline, the former Wallsend Boys Club defender cut the ball into Mavididi's path before the 17-year-old struck a clinical effort beyond the Falcons goalkeeper.
In the 26th minute, Newcastle doubled their advantage through Miley's impressive finish. After left-back Jordan Hackett burst down the left wing, the London-born teenager crossed the ball into the midfielder's path, who slammed a powerful volley into the net.
Ndiweni added United's third in the 33rd minute as the 18-year-old striker, who signed his first professional contract with his boyhood club last summer, connected with Crossley's teasing delivery into the penalty area from the left flank before guiding the ball into the far right-hand corner.
In the second-half, Newcastle extended their lead further as Ndiweni grabbed his brace, racing onto Sean Neave's pass before calmly lifting the ball over the Falcons goalkeeper into the net.
Newcastle goalkeeper Max Thompson, a representative of England at under-18 level, was rarely troubled in-between the sticks but did ensure United's clean sheet with a comfortable save to deny the Falcon forward.
In the 75th minute, Crossley added Newcastle's fifth of the afternoon as the Murton-born youngster capitalised on a defensive error, intercepting a misplaced pass before cooly slotting the ball home after rounding the Falcons goalkeeper.
Ndiweni claimed his treble in the 80th minute as the striker fired a neat first-time effort into the left-hand corner, after impressive work from Miley on the right flank, to add gloss to the scoreline.
Newcastle United Academy: Max Thompson (Taylor Ross 79), Josh Stewart, Logan Watts, Harry Powell (Luke Craggs 45), Jordan Hackett, Nathan Carlyon (c), Jamie Miley, Shaun Mavididi (Sean Neave 60), Darren Palmer (Rory Powell 45), Kyle Crossley, Michael Ndiweni.
Subs not used: Ciaran Thompson, Johnny Emerson, Dylan Charlton.
