The Magpies will look to move on from the midweek Champions League defeat to Borussia Dortmund with victory at Molineux against a Wolves side who are unbeaten in their last three outings.
And head coach Howe feels that Gary O'Neil's men - who currently sit 12th in the table - have some "dangerous" players his side will need to keep quiet if they're to extend their five-match league unbeaten run.
He also provided an update on the injuries suffered by Alexander Isak and Jacob Murphy on Wednesday night, as well as Joe Willock's ongoing return to full fitness after the midfielder made a second half cameo against the German giants last time out.
Here are some of the main topics up for discussion when Howe spoke to the media at United's Benton training centre on Friday morning:
On Wolves, who beat reigning champions Manchester City at the start of their promising run last month...
"Gary O'Neil has done a great job - it was a big task for him going in there. He has done well, the wins against Manchester City and Bournemouth were good results.
"They have some really dangerous players. We will have to be alert and recover very quickly from Wednesday night."
On Willock's return to action after six months out with injury...
"(It's) huge for us. It has been a long time. Joe is an infectious character, very popular around the training ground. He has the goalscoring and running capabilities that suit our style. It's early days, but hopefully he can get that match sharpness back."
On the injuries suffered by Isak and Murphy against Dortmund...
"Alexander Isak's got a groin injury, which we don't think is serious. It is a reoccurrence of the one he suffered for Sweden.
"Jacob is going to see a specialist today for his shoulder. We'll know more on him later today.
"We are a bit light in attacking areas. We have a deeper squad this season, but if you get injuries in certain areas then suddenly you can look a bit stretched."
On full back Matt Targett, who appeared as a substitute in midweek...
"Matt was a regular player for us. He'd done really well in our fight to stay in the Premier League. Then he got ill before that Fulham game. We won that game and performed really well as a team, so I stuck with that team. We went on a winning run and it made it difficult for him to get his place back, and Dan (Burn) in his position has been a model of consistency. They are very different players.
"I rate Matt very highly - I really do. It's great to see him come in and do so well. I think he made a positive impact on the team's performance on Wednesday."
On Sandro Tonali's availability...
"We haven't had any official confirmation yet. We haven't had anything from the Italian authorities at the moment. There is a high chance that he could be available for us at Wolves.
"His mood is the same, he is good around the group and the training ground. We will have to see what happens. We are preparing as if he is fit and ready to play. He will be travelling with us."