The young Magpies will be looking to return to winning ways against their North East neighbours under the floodlights, and coverage will begin from 6.40pm (BST).
Rising stars Elliot Anderson and Joe White have played for United's under-23s in recent weeks, while Mexican teenager Santiago Muñoz has now arrived in the country following his move from Santos Laguna and is pushing for his debut.
Supporters can watch the game for free - with commentary from John Middleton - on NUFC TV or via the official Newcastle United YouTube channel.