United will take on the Portuguese giants in the Eusébio Cup - an invitational match hosted by Benfica, with Real Madrid, Inter Milan, Ajax and São Paulo among the teams to have taken part in previous years - with an 8pm (local time and BST) kick-off.
Last season, Benfica finished third in Portugal's Primeira Liga and reached the last eight of the Champions League.
The game will be available to watch - in the UK and Saudi Arabia only - for free on NUFC TV.
NUFC TV is compatible with Chromecast, meaning you can stream the game via your television.
The Magpies' pre-season matches against 1860 Munich and Mainz 05 in Austria earlier this month were broadcast live on NUFC TV, with thousands of supporters tuning in to watch Eddie Howe's side.
However, due to UEFA broadcasting restrictions, Saturday's friendly against Athletic Bilbao at St. James' Park can not be broadcast live in the UK.
Tickets for that game, and Friday's clash with Athletic Bilbao, remain on sale here. Prices are currently £20 for adults and £10 concessions, but increase to £25 and £15 respectively on the day of each game, while there will be no cash turnstiles in operation.