The young Magpies will compete in Premier League 2 Division Two and host their Royals counterparts at Whitley Park in their opening league fixture on Monday, 16th August (kick-off 7pm BST).
Chris Hogg's side are part of a 14-team division this year as they bid to gain promotion to the top tier.
Playing their home games at Whitley Park in Benton, United's youngsters are also set to play two fixtures at St. James' Park - the Tyne-Tees derby with Middlesbrough in October as well as their penultimate league encounter of the season against Southampton in April.
Newcastle's second-string will face local rivals Sunderland at the Stadium of Light on Monday, 18th October before hosting the Black Cats at Whitley Park on Monday, 6th December.
See the full Premier League 2 fixture list for Newcastle United Under-23s below. These remain subject to change.
AUGUSTMonday 16th - Reading (H) - 7pmMonday 23rd - Birmingham City (A) - 7pmFriday 27th - Burnley (H) - 7pm
SEPTEMBERMonday 13th - West Bromwich Albion (A) - 7pmMonday 20th - Stoke City (H) - 7pmFriday 24th - Fulham (A) - 1pm
OCTOBER
Friday 1st - Middlesbrough (St. James' Park) - 7pmMonday 18th - Sunderland (A) - 7pmMonday 25th - Wolverhampton Wanderers (H) - 7pmFriday 29th - Norwich City (H) - 7pm
NOVEMBER
Friday 5th - Southampton (A) - 7pmMonday 22nd - Nottingham Forest (A) - 7pmMonday 29th - Aston Villa (H) - 7pm
DECEMBER
Monday 6th - Sunderland (H) - 7pmMonday 20th - Wolverhampton Wanderers (A) - 7pm
JANUARY
Monday 10th - West Bromwich Albion (H) - 7pmMonday 17th - Reading (A) - 7pmMonday 24th - Nottingham Forest (H) - 7pm
FEBRUARY
Monday 7th - Burnley (A) - 7pmMonday 21st - Fulham (H) - 7pmMonday 28th - Norwich City (A) - 7pm
MARCH
Monday 14th - Birmingham City (H) - 7pmMonday 21st - Stoke City (A) - 7pm
APRIL
Sunday 3rd - Middlesbrough (A) - 1pmMonday 25th - Southampton (St. James' Park) - 7pm
MAY
Monday 2nd - Aston Villa (A) - 7pm
