The young Magpies will make the trip to Spennymoor's home ground, The Brewery Field, on Saturday, 15th July to face non-league side Hebburn in a 30-minute contest (kick-off 1pm BST).
United's second-string will then take on the Moors, who compete in the National League North, in a further half-hour clash (kick-off 1.45pm BST) before Spennymoor and Hebburn later lock horns in a contest lasting one hour.
Spennymoor will then face Hebburn in a repeat of last month's Durham Challenge Cup final before the Moors later celebrate the 10-year anniversary of their FA Vase victory against Tunbridge Wells as players from both sides who featured that day at Wembley Stadium going head-to-head at The Brewery Field.
Tickets are priced at £10 Adults and £5 Concessions (60 and over), while it's £3 for under-18s. Fans can pay cash and card on the turnstiles, with no segregation in place.
Further friendly fixtures for Newcastle United Under-21s will be announced on nufc.co.uk in due course.