The Magpies face the Italian giants at St. James' Park (kick-off 8pm GMT) looking for the win that could seal their progress to the knockout stage of the competition.
But the Serie A side also have plenty to play for with their own qualification on the line, while Borussia Dortmund and Paris Saint-Germain - who face each other in their final match - are also uncertain of their fate as Group F reaches its crescendo on the final day.
Eddie Howe's side trained in front of the cameras at their Benton training base on Tuesday morning and have been handed a boost recently after an injury-ravaged few months, with Callum Wilson - who made his return to action as a substitute at Spurs on Sunday - among those who were out preparing for the midweek game.
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