Wilson, who scored in Newcastle's 2-0 win against Manchester United last weekend after his introduction from the substitutes' bench, is in from the start, replacing Alexander Isak, as the striker aims to continue his bright goalscoring form against the Hammers, scoring three times in his last three starts against the East London outfit.
Joelinton is also brought into the starting XI for this evening's clash at the London Stadium and replaces Joe Willock, who scored the opener against the Red Devils on Sunday.
Nick Pope, who recorded his 13th Premier League clean sheet last weekend, maintains his place in between the sticks while Fabian Schär and Sven Botman both remain at the heart of the United backline.
Kieran Trippier and Dan Burn, in line to make his 50th appearance for his boyhood club, will occupy the defensive flanks.
Bruno Guimarães and Sean Longstaff retain their places in the middle of the park while Jacob Murphy and Allan Saint-Maximin will aim to provide attacking support for Wilson, who scored on his Newcastle United debut away at West Ham on the opening day of the 2020/21 campaign.
There are a number of attacking options for Howe to deploy from the substitutes' bench this evening, including Isak and Willock as well as Anthony Gordon, who made his Magpies debut in the reverse fixture against David Moyes' men in February, and Elliot Anderson, who is awaiting a maiden Premier League strike for his hometown club.
There are further options for Howe to pick from, including the experienced defensive quartet of Jamaal Lascelles, Matt Targett, Matt Ritchie and Javier Manquillo.
Newcastle United: Nick Pope, Kieran Trippier (c), Fabian Schär, Sven Botman, Dan Burn, Bruno Guimarães, Sean Longstaff, Joelinton, Jacob Murphy, Allan Saint-Maximin, Callum Wilson.
Substitutes: Martin Dúbravka, Javier Manquillo, Jamaal Lascelles, Matt Targett, Matt Ritchie, Joe Willock, Elliot Anderson, Anthony Gordon, Alexander Isak.