Joe Willock, the former Arsenal man, comes in for Jacob Murphy, with Willock having now overcome the illness which had affected him at the end of last week and the beginning of this.

And Bruno Guimarães is also available after his partner, Ana, gave birth to the couple's first son, Matteo, on Friday. The Brazilian midfielder travelled to the capital separately from his team-mates, but linked up with them on Saturday night.

Joelinton has shrugged off the injury which forced him off at half time in the midweek win against Everton, while Javier Manquillo is named on the bench, with Elliot Anderson not having made the trip to North London.

Nick Pope starts in goal looking to record a third successive clean sheet, while right-back Kieran Trippier captains United against his former club. Dan Burn continues at left-back, with Sven Botman and Fabian Schär in central defence.

Willock's introduction hints at a possible change of shape, with Joelinton, Guimarães and Sean Longstaff in midfield and Miguel Almirón aiming to add to the four goals he has already scored this month. Callum Wilson - who scored a late equaliser in this fixture just over two years ago and also netted against Spurs at St. James' Park last season - starts up front.

Murphy, who had started the previous four games, is among the substitutes. Manquillo, Loris Karius, Jamal Lewis, Matt Targett, Jamaal Lascelles, Jonjo Shelvey, Ryan Fraser and Chris Wood are the other options from the bench.

Newcastle United: Nick Pope, Kieran Trippier, Fabian Schär, Sven Botman, Dan Burn, Joelinton, Sean Longstaff, Bruno Guimarães, Joe Willock, Miguel Almirón, Callum Wilson

Substitutes: Loris Karius, Javier Manquillo, Jamal Lewis, Matt Targett, Jamaal Lascelles, Jonjo Shelvey, Jacob Murphy, Ryan Fraser, Chris Wood